Cancer cells rewire metabolism to meet biosynthetic and energetic demands.The characteristic increase in glycolysis, i.e., Warburg effect, now considered as a hallmark, supports cancer in various ways.To attain such metabolic reshuffle, cancer cells preferentially re-express the M2 isoform of pyruvate kinase (PKM2, M2-PK) filter wire and alter its
Abstract Certification of quantum nonlocality plays a central role in practical applications like device-independent quantum cryptography and random number generation protocols.These applications entail the challenging problem of certifying quantum nonlocality, something that is hard to achieve when the target quantum state is only weakly entangled
Applications of metal oxide nanoparticles in the agriculture sector are being extensively included as the materials are considered superior.In the present work, zinc oxide nanoparticle (ZnO NPs), with a developing fertilizer, is applied in the fortification of rice grain yield and nutrient uptake enhancement.To evaluate the role of ZnO NP, two fiel
A simple optimization strategy for the computation of 3D finite-differencing Essential Nutrition kernels on many-cores architectures is proposed.The 3D finite-differencing computation is split direction-by-direction and exploits two level of parallelism: in-core vectorization and multi-threads shared-memory parallelization.The main application of t
Building on the social identity theory, this conceptual article proposes a process model to understand the linkage between workplace humor and the social identity change experiences of employees.Further, it identifies the underlying mechanisms and conditions which impact the positive and negative identity changes during this process.Based on the pr